Diltiazem may increase the hypotensive activities of Cicletanine. You may notice that your heart beats more quickly than normal and that you feel shaky. I am not going to describe how bad it was because it doesnвЂ™t have to be that way for everybody. The metabolism of clomethiazole can be decreased when combined with Venlafaxine. However, it is almost certainly safer to take AEDs while pregnant than to have seizures. The metabolism of Amitriptyline can be decreased when combined with Rucaparib.