Fluconazole did not affect the fertility of male or female rats treated orally with daily doses of 5, 10, or 20 mg/kg or with parenteral doses of 5, 25, or 75 mg/kg, although the onset of parturition was slightly delayed at 20 mg/kg PO. Seeman P, Watanabe M, Grigoriadis D, et al. It has been studied for the prevention of postoperative complications after heart surgery. They are not reported in scientific journals. Administration via nebulization does not appear to significantly alter the pharmacokinetics of albuterol. Peak cardiac effects occur 3-6 hours following ingestion and may persist for 24В hours or longer.